99% Fluconazole CAS 86386-73-4

Short Description:

Chemical name: Fluconazole

Other name: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol

CAS No.: 86386-73-4

Purity: 99%

Molecular Formula: C13H12F2N6O

Molecular Weight: 306.27

Standard: USP/BP/EP/CP/JP

Chemical Properties: White to off-white crystalline powder, slightly different odor, bitter taste. Soluble in glacial acetic acid, methanol or ethanol, hardly soluble in water, almost insoluble in ether. It is a fluorinated triazole broad-spectrum antifungal drug, the antibacterial spectrum is similar to that of ketoconazole, long-acting, effective for deep infection fungal drugs, strong antifungal effect, and good oral absorption. Mainly used for candidiasis and cryptococcosis, also effective for oropharyngeal candidiasis in cancer patients.

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Fluconazole is a fluorinated triazole antifungal drug with a similar antibacterial spectrum to ketoconazole and stronger antibacterial activity than ketoconazole. Its mechanism of action is to inhibit ergosterol synthase, an essential component of fungal cell membranes, block ergosterol synthesis, destroy the integrity of fungal cell walls, and inhibit its growth and reproduction.

The product has strong antibacterial activity against Candida albicans, Microsporum, Cryptococcus neoformans, Epidermophyton and Histoplasma capsulatum. It is well absorbed orally, widely distributed in the body, and can penetrate into the cerebrospinal fluid. Clinically, it is mainly used for vaginal candidiasis, thrush, atrophic oral candidiasis, fungal meningitis, pulmonary fungal infection, abdominal infection, urinary tract infection and skin fungal infection.